Use of magnetotactic bacteria in oncology



Credit: St. Petersburg Electrotechnical University LETI

Kamil Gareev, associate professor at ETU “LETI”, justified the prospects of using magnetotactic bacteria to treat malignant tumors.

LETI researchers have identified the main properties of magnetotactic bacteria and described the possibilities of their application in medicine. The results obtained will make it possible to create theranostic agents in neuro oncology and cardioprotection. The results of the joint study with colleagues from St. Petersburg State University, RAS Institute of Cytology, and RAS Institute of Biotechnology were published in a review article in the journal. Magnetochemistry.

Magnetotactic bacteria (MTB) are distinguished by their ability to synthesize magnetosomes, particular cellular organelles in which the biomineralization of magnetite occurs. Thanks to their magnetic properties, MTBs and isolated magnetosomes can be used medicinally to fight cancer. Using magnetosomes, drugs can be transported directly to the malignant tumor. In addition, the scientists aim to study the formation of bacterial magnetite crystals inside MTB cells, the mechanisms of magnetostatic interaction between individual magnetosomes and their chemical and aggregative stability outside bacterial cells. These results will become the core of research in paleomagnetism and the physics of magnetic phenomena.

LETI research will help apply magnetotactic bacteria in oncology

Kamil Gareev, associate professor in the department of micro- and nanoelectronics at LETI. Credit: St. Petersburg Electrotechnical University

Currently, scientists from Germany, France, Brazil, the United States and Japan are engaged in large-scale research on magnetotactic bacteria. The research by LETI scientists will be the first in St. Petersburg. LETI has chosen an interdisciplinary approach: the university has formed a research team, which includes specialists from different fields: physics of magnetic phenomena, magnetism of rocks and magnetofossils, neuro oncology and therapy of targets based on nanoparticles, as well as the synthesis of composite magnetic particles based on iron oxide. This will make it possible to carry out a multipurpose study and obtain objective results.

“We plan to eventually complete the full cycle of research, from fermentation of MTBs in high-volume, high-volume automated bioreactors and evaluation of their physical characteristics to functionalization of magnetosomes with pharmaceuticals and their assays. laboratory. Thus, subject to the achievement of the overall objectives, for the first time in our city there will be world-class results in this field of science, ”said Gareev, associate professor of the department of micro- and nanoelectronics of LETI, principal researcher of the Engineering Center for Microtechnology and Diagnostics

The next step in the study of VTT will bring scientists closer to the practical use of bacterial magnetosome-based structures in medicine as new tools for targeted drug delivery, hyperthermia therapy, and contrast agents for the ‘Magnetic resonance imaging. “Compared to currently used structures based on synthetic iron oxide nanoparticles, bacterial magnetite exhibits better chemical stability, high uniformity of shape and size and, more importantly, high biocompatibility,” commented Gareev.

LETI scientists obtained the first results of the study of magnetic nanoparticles in 2013, and since then, research in this direction has continued. Until 2021, research has mainly focused on the properties of synthetic rather than biogenic magnetic nanoparticles, such as magnetosomes. The long-term experience allowed the researchers to move on to a full-fledged study of magnetotactic bacteria and bacterial magnetosomes.

Bacterial magnetic nanoparticles for biomedical applications

More information:
Kamil G. Gareev et al, Magnetotactic bacteria and magnetosomes: basic properties and applications, Magnetochemistry (2021). DOI: 10.3390 / magnetochemistry7060086

Provided by St. Petersburg Electrotechnical University LETI

Quote: Use of magnetotactic bacteria in oncology (2021, July 15) retrieved July 15, 2021 from

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